Antithyroid Activity of 6-Chloropurine
نویسندگان
چکیده
A atividade antitireóidea do 6-cloropurina, in vitro, foi determinada espectrofotometricamente por estudos de formação de seu complexo com iodo. O complexo mostrou estequiometria de 1:1. A constante de formação do complexo encontrada foi 7,652 × 10 L mol, o que indicou um bom potencial de 6-cloropurina, como agente antitireóideo. Posteriores verificações mostraram mudanças nos níveis hormonais tireóideos em coelhos machos, in vivo, após administração da dose via intraperitoneal (i.p.) durante 14 dias e medindo os níveis de triiodotironina (T 3 ) e tetraiodotironina (T 4 ) livres, na circulação sanguínea, usando-se a técnica de radioimunoensaio. As análises de sangue mostraram decréscimo nos níveis de T 3 e T 4 livres em animais tratados, quando comparados com os controles. Desta maneira, confirmou-se uma boa atividade antitireóidea do 6-cloropurina.
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